Cancer metabolism
It is well known that cancer cells rewire their metabolism to obtain a survival advantage in nutrient-deprived conditions. In particular, cancer cells are notorious for upregulating various metabolic pathways for nutrient scavenging, such as autophagy or macropinocytosis. Also, these cells can regulate nutrient transporters to gain a survival advantage. We are interested in studying the underlying mechanisms for these reprogrammed metabolic pathways and further exploiting them for therapeutic treatments. |
Ferroptosis
Initiating cell death in cancers is the ultimate goal of many cancer therapeutics. Ferroptosis is a non-apoptotic cell death program that is caused by lipid peroxidation in an iron-dependent manner. We are interested in studying the mechanism of ferroptosis and its regulation in disease states such as cancer or degenerative diseases. |